On a model mechanism for the spatial patterning of teeth primordia in the Alligator

We propose a model mechanism for the initiation and spatial positioning of teeth primordia in the alligator,Alligator mississippiensis. Detailed embryological studies by Westergaard & Ferguson (1986, 1987, 1990) show that jaw growth plays a crucial role in the developmental patterning of the tooth initiation process. Based on biological data we develop a reaction-diffusion mechanism, which crucially includes domain growth. The model can reproduce the spatial pattern development of the first seven teeth primordia in the lower half jaw ofA. mississippiensis. The results for the precise spatio-temporal sequence compare well with detailed developmental experiments

User manual for Streamtube Curvature Analysis: Analytical method for predicting the pressure distribution about a nacelle at transonic speeds, appendix

The computer program listing of Streamtube Curvature Analysis is presented. The listing includes explanatory statements and titles so that the program flow is readily discernable. The computer program listing is in CDC FORTRAN 2.3 source language form, except for three subroutines, GETIX, GETRLX, and SAVIX, which are in COMPOSE 1.1 language

Bias spectroscopy and simultaneous SET charge state detection of Si:P double dots

We report a detailed study of low-temperature (mK) transport properties of a silicon double-dot system fabricated by phosphorous ion implantation. The device under study consists of two phosphorous nanoscale islands doped to above the metal-insulator transition, separated from each other and the source and drain reservoirs by nominally undoped (intrinsic) silicon tunnel barriers. Metallic control gates, together with an Al-AlOx single-electron transistor, were positioned on the substrate surface, capacitively coupled to the buried dots. The individual double-dot charge states were probed using source-drain bias spectroscopy combined with non-invasive SET charge sensing. The system was measured in linear (VSD = 0) and non-linear (VSD 0) regimes allowing calculations of the relevant capacitances. Simultaneous detection using both SET sensing and source-drain current measurements was demonstrated, providing a valuable combination for the analysis of the system. Evolution of the triple points with applied bias was observed using both charge and current sensing. Coulomb diamonds, showing the interplay between the Coulomb charging effects of the two dots, were measured using simultaneous detection and compared with numerical simulations.Comment: 7 pages, 6 figure

Description of an ancient social bee trapped in amber using diagnostic radioentomology

The application of non-invasive imaging technologies using X-radiation (diagnostic radioentomology, ‘DR') is demonstrated for the study of amber-entombed social bees. Here, we examine the external and internal morphology of an Early Miocene (Burdigalian) stingless bee (Apinae: Meliponini) from the Dominican Republic using non-destructive X-ray microtomography analysis. The study permits the accurate reconstruction of features otherwise obscured or impossible to visualize without destroying the sample and allows diagnosis of the specimen as a new species, Proplebeia adbita Greco and Enge

Measurements of the Diffuse Ultraviolet Background and the Terrestrial Airglow with the Space Telescope Imaging Spectrograph

Far-UV observations in and near the Hubble Deep Fields demonstrate that the Space Telescope Imaging Spectrograph (STIS) can potentially obtain unique and precise measurements of the diffuse far-ultraviolet background. Although STIS is not the ideal instrument for such measurements, high-resolution images allow Galactic and extragalactic objects to be masked to very faint magnitudes, thus ensuring a measurement of the truly diffuse UV signal. The programs we have analyzed were not designed for this scientific purpose, but would be sufficient to obtain a very sensitive measurement if it were not for a weak but larger-than-expected signal from airglow in the STIS 1450-1900 A bandpass. Our analysis shows that STIS far-UV crystal quartz observations taken near the limb during orbital day can detect a faint airglow signal, most likely from NI\1493, that is comparable to the dark rate and inseparable from the far-UV background. Discarding all but the night data from these datasets gives a diffuse far-ultraviolet background measurement of 501 +/- 103 ph/cm2/sec/ster/A, along a line of sight with very low Galactic neutral hydrogen column (N_HI = 1.5E20 cm-2) and extinction (E(B-V)=0.01 mag). This result is in good agreement with earlier measurements of the far-UV background, and should not include any significant contribution from airglow. We present our findings as a warning to other groups who may use the STIS far-UV camera to observe faint extended targets, and to demonstrate how this measurement may be properly obtained with STIS.Comment: 7 pages, Latex. 4 figures. Uses corrected version of emulateapj.sty and apjfonts.sty (included). Accepted for publication in A

Rabies elimination research: juxtaposing optimism, pragmatism and realism

More than 100 years of research has now been conducted into the prevention, control and elimination of rabies with safe and highly efficacious vaccines developed for use in human and animal populations. Domestic dogs are a major reservoir for rabies, and although considerable advances have been made towards the elimination and control of canine rabies in many parts of the world, the disease continues to kill tens of thousands of people every year in Africa and Asia. Policy efforts are now being directed towards a global target of zero human deaths from dog-mediated rabies by 2030 and the global elimination of canine rabies. Here we demonstrate how research provides a cause for optimism as to the feasibility of these goals through strategies based around mass dog vaccination. We summarize some of the pragmatic insights generated from rabies epidemiology and dog ecology research that can improve the design of dog vaccination strategies in low- and middle-income countries and which should encourage implementation without further delay. We also highlight the need for realism in reaching the feasible, although technically more difficult and longer-term goal of global elimination of canine rabies. Finally, we discuss how research on rabies has broader relevance to the control and elimination of a suite of diseases of current concern to human and animal health, providing an exemplar of the value of a ‘One Health’ approach

The Rest-Frame UV Luminosity Density of Star-Forming Galaxies at Redshifts z>3.5

We have measured the rest--frame lambda~1500 Ang comoving specific luminosity density of star--forming galaxies at redshift 3.5<z<6.5 from deep images taken with the Hubble Space Telescope (HST)and the Advanced Camera for Surveys (ACS), obtained as part of the Great Observatories Origins Deep Survey (GOODS). We used color selection criteria to construct samples of star--forming galaxies at redshifts z~4, 5 and 6, identified by the signature of the 912 Ang Lyman continuum discontinuity and Lyman-alpha forest blanketing in their rest--frame UV colors (Lyman--break galaxies). The ACS samples cover ~0.09 square degree, and are also relatively deep, reaching between 0.2 and 0.5 L_3^*, depending on the redshift, where $L_3^*$ is the characteristic UV luminosity of Lyman--break galaxies at z~3. The specific luminosity density of Lyman--break galaxies appears to be nearly constant with redshift from z~3 to z~6, although the measure at z~6 remains relatively uncertain, because it depends on the accurate estimate of the faint counts of the z~6 sample. If Lyman--break galaxies are fair tracers of the cosmic star formation activity, our results suggest that at z~6 the universe was already producing stars as vigorously as it did near its maximum several Gyr later, at 1<~z<~3. Thus, the onset of large--scale star formation in the universe is to be sought at around z~6 or higher, namely at less than ~7% of the current cosmic age.Comment: AAS LaTeX macros 4.0, 11 pages, 1 postscript figure. Accepted for publication in The Astrophysical Journal, Letter. Minor changes to the figure caption. The data and the GOODS-group papers can be found at http://www.stsci.edu/science/goods

The Large-scale and Small-scale Clustering of Lyman-Break Galaxies at 3.5 < z< 5.5 from the GOODS survey

We report on the angular correlation function of Lyman-break galaxies (LBGs) at z~4 and 5 from deep samples obtained from the Great Observatories Deep Origins Survey (GOODS). Similar to LBGs at z~3, the shape of w(theta) of the GOODS LBGs is well approximated by a power-law with slope beta~0.6 at angular separation theta > 10 arcsec. The clustering strength of z~4, 5 LBGs also depends on the rest-frame UV luminosity, with brighter galaxies more strongly clustered than fainter ones, implying a general correlation between halos' mass and LBGs' star-formation rate. At smaller separations, w(theta) of deep samples significantly exceeds the extrapolation of the large-scale power-law fit, implying enhanced spatial clustering at scales r < 1 Mpc. We also find that bright LBGs statistically have more faint companions on scales theta < 20 arcsec than fainter ones, showing that the enhanced small-scale clustering is very likely due to sub-structure, namely the fact that massive halos can host multiple galaxies. A simple model for the halo occupation distribution and the CDM halo mass function reproduce well the observed w(theta). The scaling relationship of the clustering strength with volume density and with redshift is quantitatively consistent with that of CDM halos. A comparison of the clustering strength of three samples of equal luminosity limit at z ~ 3, 4 and 5 shows that the LBGs at z~5 are hosted in halos about one order of magnitude less massive than those in the lower redshift bins, suggesting that star-formation was more efficient at higher-redshift.Comment: replaced with the version accepted for publication in ApJ. 46 pages, 10 figures; minor changes to text, one subsection adde

Spectroscopic Observations of Lyman-Break Galaxies at Redshift ~ 4, 5 and 6 in the GOODS-South Field

We report on observations of Lyman-break galaxies (LBGs) selected from the Great Observatories Origins Deep Survey at mean redshift z~4, 5 and 6, obtained with FORS2 spectrograph at the ESO-VLT.This program has yielded spectroscopic identifications for 114 galaxies of which 51 are at z~4, 31 at z~5, and 32 at z~6. The adopted selection criteria are effective, identifying galaxies at the expected redshift with minimal foreground contamination. Once selection effects are properly accounted for, the rest-frame UV spectra of the higher-redshift LBGs appear to be similar to their counterparts at z~3. As at z~3, LBGs at z~4 and z~5 show Lya both in emission and in absorption; when in absorption, strong interstellar lines and red UV spectra are observed, a fact also measured at z~2 and 3. At z~6, sensitivity issues bias our sample towards galaxies with Lya in emission; nevertheless, these spectra appear to be similar to their lower-redshift counterparts. As in other studies at similar redshifts, we find clear evidence that brighter LBGs tend to have weaker Lya emission lines. At fixed rest-frame UV luminosity, the equivalent width of the Lya emission line is larger at higher redshifts. At all redshifts where the measurements can be reliably made, the redshift of the Lya emission line turns out to be larger than that of the interstellar absorption lines,with a median velocity difference DeltaV~400 km/s at z~4 and 5, consistent with results at lower redshifts. This shows that powerful, large-scale winds are common at high redshift.In general,there is no strong correlation between the morphology of the UV light and the spectroscopic properties. However, galaxies with deep interstellar absorption lines and strong Lya absorption appear to be more diffuse than galaxies with Lya in emission.(abridged)Comment: 58 pages, 19 figures, accepted for publication in The Astrophysical Journa